News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

Date Published
(Funded by the National Institutes of Health)

Researchers from the University of Michigan have reported a new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier that could deliver cancer-killing drugs directly to malignant brain tumors. The discovery, demonstrated in mice, could enable new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults.

(Funded by the National Institutes of Health)

Researchers from the University of Michigan have reported a new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier that could deliver cancer-killing drugs directly to malignant brain tumors. The discovery, demonstrated in mice, could enable new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults.

(Funded by the National Institutes of Health)

Researchers at the University of Maryland School of Medicine have developed a new nanoparticle drug formulation that targets a specific receptor on cancer cells and appears to be more effective than a standard nanoparticle therapy currently on the market to treat metastatic breast cancer. The study found that the new nanoparticles bypass healthy cells and tissues and bind to tumor cells, dispersing evenly throughout the tumor while releasing the chemotherapy drug paclitaxel.

(Funded by the National Science Foundation)

Researchers at Rice University have developed a new cost-effective technology for desalinating industrial-strength brine by using a thin coating of the 2D nanomaterial hexagonal boron nitride. Boron nitride’s combination of chemical resistance and thermal conductivity facilitated a system that produced a flux of more than 42 kilograms of water per square meter of membrane per hour — more than 10 times greater than ambient solar membrane distillation technologies — at an energy efficiency much higher than existing membrane distillation technologies.

(Funded by the National Science Foundation)

Researchers at Rice University have developed a new cost-effective technology for desalinating industrial-strength brine by using a thin coating of the 2D nanomaterial hexagonal boron nitride. Boron nitride’s combination of chemical resistance and thermal conductivity facilitated a system that produced a flux of more than 42 kilograms of water per square meter of membrane per hour — more than 10 times greater than ambient solar membrane distillation technologies — at an energy efficiency much higher than existing membrane distillation technologies.

(Funded by the U.S. Department of Defense)

Researchers at the University of Washington have designed the first end-to-end molecular tagging system that enables rapid, on-demand encoding and decoding at scale. Instead of radio waves or printed lines, the tagging scheme relies on a set of distinct DNA strands called molecular bits, or “molbits” for short, that incorporate highly separable nanopore signals to ease later readout. The molbits are extremely tiny, making them ideal for tracking small items or flexible surfaces that aren’t suited to conventional tagging methods.

(Funded by the U.S. Department of Defense)

Researchers at the University of Washington have designed the first end-to-end molecular tagging system that enables rapid, on-demand encoding and decoding at scale. Instead of radio waves or printed lines, the tagging scheme relies on a set of distinct DNA strands called molecular bits, or “molbits” for short, that incorporate highly separable nanopore signals to ease later readout. The molbits are extremely tiny, making them ideal for tracking small items or flexible surfaces that aren’t suited to conventional tagging methods.

(Funded by the U.S. Department of Defense and the National Science Foundation)

Penn State researchers have reported advancing the development of “smart glass,” or glass equipped with automatic sensing properties. The Penn State team integrated atomically thin molybdenum disulfide in photosensors with durable materials such as those currently used in smartphone screens. This technology could be applied in biomedical imaging, security surveillance, environmental sensing, optical communication, night vision, motion detection, and collision avoidance systems for autonomous vehicles and robots. 

(Funded by the U.S. Department of Defense and the National Science Foundation)

Penn State researchers have reported advancing the development of “smart glass,” or glass equipped with automatic sensing properties. The Penn State team integrated atomically thin molybdenum disulfide in photosensors with durable materials such as those currently used in smartphone screens. This technology could be applied in biomedical imaging, security surveillance, environmental sensing, optical communication, night vision, motion detection, and collision avoidance systems for autonomous vehicles and robots. 

(Funded by the National Institutes of Health and the National Science Foundation)

Scientists at the University of Washington have developed a nanoparticle-based drug delivery system that can ferry a potent anti-cancer drug through the bloodstream safely and inhibit tumor growth in mice. The nanoparticle is derived from chitin, a natural and organic polymer that makes up the outer shells of shrimp. The nanoparticles showed no adverse side effects, likely since they are derived in part from naturally occurring polymers.