Chemists at the Massachusetts Institute of Technology and the Dana-Farber Cancer Institute have designed a bottlebrush-shaped nanoparticle that can be loaded with multiple cancer drugs in ratios that can be easily controlled. In a study with mice, the researchers showed that nanoparticles carrying three drugs in the synergistic ratio they identified shrank tumors much more than when the three drugs were given at the same ratio but untethered to a nanoparticle. This nanoparticle platform could potentially be deployed to deliver drug combinations against a variety of cancers.
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